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Acute megakaryoblastic leukemia : ウィキペディア英語版
Acute megakaryoblastic leukemia

Acute megakaryoblastic leukemia (AMKL) is a form of leukemia where a majority of the blasts are megakaryoblastic.
It is classified under M7 in the French-American-British classification.〔(【引用サイトリンク】title=Acute Myeloid Leukemia - Signs and Symptoms )
This category of AML is associate with 30% or more blasts in the marrow, blast are identified as being of megakaryocyte lineage by expression of megakaryocyte specific antigens and platelet peroxidase reaction on electron microscopy.
==Causes==
It is associated with GATA1, and risks are increased in individuals with Down syndrome.
However, not all cases are associated with Down syndrome, and other genes can also be associated with AMKL.
Another related gene is MKL1, which is also known as "MAL". This gene is a cofactor of serum response factor.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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